Jeff Krise

Jeff Krise
  • Associate Professor
  • Department of Pharmaceutical Chemistry

Contact Info

Simons Biosciences Research Laboratories, Room 256
2093 Constant Avenue
Lawrence, KS 66047


Professional Experience

  • Associate Professor, University of Kansas, Department of Pharmaceutical Chemistry (2004 - present)
  • University of North Carolina at Chapel Hill, Division of Drug Delivery (2001)


Postdoctoral, Department of Biochemistry, Stanford University School of Medicine, 2001, Stanford, CA
Postdoctoral, Victorian College of Pharmacy (now Monash University), Melbourne, Austrailia
Ph.D. (w/honors), Pharmaceutical Chemistry, University of Kansas, 1998, Lawrence, KS
B.S. in Pharmacy, Duquesne University, 1993, Pittsburgh, PA


The Krise laboratory seeks to understand how drugs distribute and localize within human cells and how this influences their therapeutic activity and pharmacokinetic distribution properties. Much of our recent studies have focused on the intracellular distribution of amine-containing drugs and their propensity to become highly concentrated in acidic intracellular compartments such as lysosomes according to an ion trapping-type mechanism.

Research Interests

  • Drug delivery
  • Pharmacokinetics
  • Prodrugs
  • Intracellular