Lab samples in glass tubes and bottles

Jeff Krise Research

Jeff Krise
Jeff Krise Research
University of Kansas
Simons Biosciences Research Laboratories, Room 236-B
2095 Constant Avenue
Lawrence, KS 66047

Research Overview

The Krise laboratory seeks to understand how drugs distribute and localize within human cells and how this influences their therapeutic activity and pharmacokinetic distribution properties. Much of our recent studies have focused on the intracellular distribution of amine-containing drugs and their propensity to become highly concentrated in acidic intracellular compartments such as lysosomes according to an ion trapping-type mechanism.

Research Interests

  • Drug delivery
  • Pharmacokinetics
  • Prodrugs
  • Intracellular

Jeff Krise Research