Teruna J. Siahaan

Aya and Takeru Higuchi Distinguished Professor
Associate Chair - Pharmaceutical Chemistry
Co-Director - NIH Biotechnology Training Program

Department of Pharmaceutical Chemistry

Contact Info

siahaan@ku.edu

785-864-7327

Simons Biosciences Research Laboratories, Room 258
2093 Constant Ave.
Lawrence, KS 66047

Teruna Siahaan Research Teruna Siahaan Research

Education —

Postdoctoral Fellow, University of California Santa Barbara

Ph.D. in Organic Chemistry, University of Arizona

M.S. in Organic Chemistry, University of Indonesia

B.S. in Chemistry, University of Indonesia

Research —

Teruna Siahaan's research interests are in the utilization and modulation of cell adhesion molecules on the cell surface for targeted drug delivery to a specific cell type and for enhancing drug permeation through the intestinal mucosa and blood-brain barrier (BBB). His group is using E-cadherin peptides to enhance permeation of large hydrophilic molecules (i.e., peptides and proteins) through the intestinal mucosa and BBB. The hypothesis is that E-cadherin peptides modulate the E-cadherin interactions at the intercellular junctions to create larger openings that will allow paracellular permeation of large hydrophilic molecules (e.g., peptides and proteins). His group is also using peptides derived from cell adhesion molecules (i.e., ICAM-1 and LFA-1) to target drugs to leukocytes and vascular endothelial cells in inflammatory and autoimmune diseases (i.e., rheumatoid arthritis). Cell adhesion peptides are being used to target antigenic peptides (i.e., bi-functional peptide inhibitor (BPI)) to block the formation of the immunological synapse at the interface between T cells and antigen presenting cells (APC). BPI molecules have been shown to suppress autoimmune disease models such as multiple sclerosis, type-1 diabetes and rheumatoid arthritis.

Selected Publications —

Moral, M. E., & Siahaan, T. J. (2017). Conjugates of Cell Adhesion Peptides for Therapeutics and Diagnostics Against Cancer and Autoimmune Diseases. Curr. Top. Med. Chem., 17(32), 3425–3443. Betham Science. DOI:10.2174/1568026618666180118154514 www.eurekaselect.com/159184/article

Kuehl, C. Thati, S. Sullivan, B. Sestak, J. Thompson, M. Siahaan, T. & Berkland, C. (2017). Pulmonary administration of soluble antigen arrays is superior to antigen in treatment of experimental autoimmune encephalomyelitis. J. Pharm. Sci. http://www.sciencedirect.com/science/article/pii/S0022354917304458

Ulapane, K. R., On, N. Kiptoo, P. Williams, T. D., Miller, D. W., & Siahaan, T. J. (2017). Improving brain delivery of biomolecules via BBB modulation in mouse and rat: Detection using MRI, NIRF, and mass spectrometry. Nanotheranostics, 1(2), 217–231. DOI:10.7150/ntno.19158 http://www.ntno.org/v01p0217

White, D. R., Khedri, Z. Kiptoo, P. Siahaan, T. J., & Tolbert, T. J. (2017). Synthesis of a bifunctional peptide inhibitor-IgG1 Fc fusion that suppresses experimental autoimmune encephalomyelitis. Bioconjugate Chemistry, E-Pub(June 5). DOI:10.1021/acs.bioconjchem.7b00175 http://pubs.acs.org/doi/abs/10.1021/acs.bioconjchem.7b00175

Obi, A. T., Andraska, E. Kanthi, Y. Kessinger, C. W., Elfline, Y. M., Luke, C. Siahaan, T. J., Jaffer, F. A., Wakefield, T. W., & Henke, P. K. (2017). Endotoxaemia-augmented murine venous thrombosis is dependent on TLR-4 and ICAM-1, and potentiated by neutropenia. Thromb. Haemost., 117(2), 339–348. DOI:10.1160/TH16-03-0218 https://th.schattauer.de/en/contents/archive/manuscript/27005.html

Alaofi, A. Farokhi, E. Prasasty, V. D., Anbanandam, A. Kuczera, K. & Siahaan, T. J. (2017). Probing the interaction between cHAVc3 peptide and the EC1 domain of E-cadherin using NMR and molecular dynamics simulations. J. Biomol. Struct. Dyn., 35(1), 92–104.=. DOI:10.1080/07391102.2015.1133321 http://www.tandfonline.com/doi/abs/10.1080/07391102.2015.1133321?journalCode=tbsd20

Obi, A. T., Andraska, E. Kanthi, Y. Luke, C. E., Elfline, M. Madathilparambil, S. Siahaan, T. J., Jaffer, F. A., Wakefield, T. W., Raghavendran, R. & Henke, P. K. (2016). Gram-negative pneumonia alters large-vein cell-adhesion molecule profile and potentiates experimental stasis venous thrombosis. J. Vasc. Res. , 53, 186–195 . DOI:10.1159/000447299 http://www.karger.com/Article/Abstract/447299

Mahzoon, S. Siahaan, T. J., & Detamore, M. S. (2016). Functionalizing With Bioactive Peptides to Generate Bio-Instructive Scaffold. (Chapter 2). In J. Brown, S. Kumbar, B. Banik, & . (Eds.), Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine . https://www.elsevier.com/books/bio-instructive-scaffolds-for-musculoskeletal-tissue-engineering-and-regenerative-medicine/unknown/978-0-12-803394-4

Büyüktimkin, B. Stewart Jr., J. Tabanor, K. Kiptoo, P. & Siahaan, T. J. (2016). Development of Therapeutic Protein and Peptide Conjugates to Make Better Drugs. (Chapter 20). In B. Wang, L. Hu, & T. J. Siahaan (Eds.), Drug Delivery: Principles and Applications(2nd ed.) (pp. 475–502). New York: John Wiley & Sons. DOI:10.1002/9781118833322

Kiptoo, P. Calcagno, A. M., & Siahaan, T. J. (2016). Physiological, Biochemical, and Chemical Barriers to Drug Delivery. (Chapter 2). In B. Wang, L. Hu, & T. J. Siahaan (Eds.), Drug Delivery: Principles and Applications(2nd ed.) (pp. 19–32). New York: John Wiley & Sons. DOI:10.1002/9781118833322

Wang, B., Hu, L., & Siahaan, T. J, (Eds.). (2016). Drug Delivery: Principles and Applications (B. Wang, L. Hu, & T. J, Siahaan, Eds.). DOI:10.1002/9781118833322

Alaofi, A. On, N. Kiptoo, P. Williams, T. D., Miller, D. W., & Siahaan, T. J. (2016). Comparison of linear and cyclic HAV peptides in modulating the blood-brain barrier permeability: Impact on delivery of molecules to the brain. J. Pharm. Sci., 105(2), 797–807. DOI:10.1016/S0022-3549(15)00188-4 http://jpharmsci.org/article/S0022-3549(15)00188-4/abstract

Tabanor, K. Lee, P. Kiptoo, P. Choi, I. Y., Sherry, E. B., Eagle, C. S., Williams, T. D., & Siahaan, T. J. (2016). Brain delivery of drug and MRI contrast agent: Detection and quantitative determination of brain deposition of CPT-Glu using LC-MS/MS and Gd-DTPA using magnetic resonance imaging. Mol. Pharm. DOI:10.1021/acs.molpharmaceut.5b00607 10.1021/acs.molpharmaceut.5b00607

Stewart, J. Badawi, A. H., Kiptoo, P. & Siahaan, T. J. (2015). Vaccine-like administration of PLP-PEG-B7AP and MOG-PEG-B7AP to control EAE in relapse-remission and chronic progressive animal models of multiple sclerosis. Oligos & Peptides-Chemica Oggi, Chemistry Today, 3341–47 , 41–47 . http://www.teknoscienze.com/tks_article/a-vaccine-like-administration-of-plp-peg-b7ap-and-mog-peg-b7ap-to-control-eae-in-relapse-remission-and-chronic-progressive-animal-models-of-multiple-sclerosis-bifunctional-peptide-inhibitors-as-pept/

Badawi, A. H., Kiptoo, P. & Siahaan, T. J. (2015). Immune tolerance induction against experimental autoimmune encephalomyelitis (EAE) using a new PLP-B7AP conjugate that simultaneously targets B7/CD28 costimulatory signal and TCR/MHC-II signal. J. Multiple Sclerosis, 2(1). DOI:10.4172/2376-0389.1000131 https://www.omicsgroup.org/journals/immune-tolerance-induction-against-experimental-autoimmune-encephalomyelitis-eae-using-2376-0389.1000131.php?aid=38669 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484621/

Mathaes, R. Winter, G. Siahaan, T. J., Besheer, A. & Engert, J. (2015). Influence of particle size, an elongated particle geometry, and adjuvants on dendritic cell activation. Eur. J. Pharm. Biopharm., 94, 542-549. DOI:10.1016/j.ejpb.2015.06.015 http://www.sciencedirect.com/science/article/pii/S0939641115002751

Prasasty, V. D., Krause, M. E., Tambunan, U. S., Anbanandam, A. Laurence, J. S., & Siahaan, T. J. (2015). (1)H, (13)C and (15)N backbone assignment of the EC-1 domain of human E-cadherin. Biomol. NMR Assign., 9(1), 31-5. DOI:10.1007/s12104-013-9539-6 http://link.springer.com/article/10.1007%2Fs12104-013-9539-6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133310/

Laksitorini, M. D., Kiptoo, P. K., On, N. H., Thliveris, J. A., Miller, D. W., & Siahaan, T. J. (2015). Modulation of intercellular junctions by cyclic-ADT peptides as a method to reversibly increase blood-brain barrier permeability. J. Pharm. Sci., 104(3), 1065–1075. DOI:10.1002/jps.24309 http://onlinelibrary.wiley.com/doi/10.1002/jps.2015.104.issue-3/issuetoc

Büyüktimkin, B. Kiptoo, P. & Siahaan, T. J. (2014). Bifunctional peptide inhibitors suppress interleukin-6 proliferation and ameliorates murine collagen-induced arthritis. J. Clin. Cell. Immunol., 5(6). DOI:10.4172/2155-9899.1000273 https://www.omicsonline.org/open-access/bifunctional-peptide-inhibitors-suppress-interleukin-proliferation-and-ameliorates-murine-collageninduced-arthritis-2155-9899-1000273.php?aid=34952 https://kuscholarworks.ku.edu/handle/1808/18508

Thati, S. Kuehl, C. Hartwell, B. Sestak, J. Siahaan, T. J., Forrest, M. L., & Berkland, C. (2014). Routes of Administration and Dose Optimization of Soluble Antigen Arrays in Mice with Experimental Autoimmune Encephalomyelitis. J. Pharm. Sci., 104(2), 714–721. DOI:10.1002/jps.24272 http://jpharmsci.org/article/S0022-3549(15)30223-9/abstract https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312227/

Northrup, L. Sestak, J. O., Sullivan, B. P., Thati, S. Hartwell, B. L., Siahaan, T. J., Vines, C. M., & Berkland, C. (2014). Co-delivery of autoantigen and B7 pathway modulators suppresses experimental autoimmune encephalomyelitis. The AAPS Journal, 16(6), 1204-13. DOI:10.1208/s12248-014-9671-y http://link.springer.com/article/10.1208%2Fs12248-014-9671-y https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389758/

Sestak, J. O., Fakhari, A. Badawi, A. H., Siahaan, T. J., & Berkland, C. (2014). Structure, size, and solubility of antigen arrays determines efficacy in experimental autoimmune encephalomyelitis. The AAPS Journal, 16(6), 1185-93. DOI:10.1208/s12248-014-9654-z http://link.springer.com/article/10.1208/s12248-014-9654-z https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389745/

Laksitorini, M. Prasasty, V. D., Kiptoo, P. K., & Siahaan, T. J. (2014). Pathways and progress in improving drug delivery through the intestinal mucosa and blood-brain barriers. Therapeutic Delivery, 5(10), 1143–1163. DOI:10.4155/tde.14.67 http://www.future-science.com/doi/abs/10.4155/tde.14.67 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445828/

Prasasty, V. D., Tambunan, U. S., & Siahaan, T. J. (2014). Homology modeling and molecular dynamics studies of EC1 domain of VE-cadherin to elucidate docking interaction with cadherin-derived peptide. OnLine Journal of Biological Sciences , 14(2), 155-162. DOI:10.3844/ojbssp.2014.155.162 http://thescipub.com/PDF/ojbsci.2014.155.162.pdf

Sestak, J. O., Sullivan, B. Thati, S. Northrup, L. Hartwell, B. Antunez, L. Forrest, L. Siahaan, T. J., & Berkland, C. (2014). Codelivery of antigen and an immune cell adhesion inhibitor is necessary for efficacy of soluble antigen arrays in experimental encephalomyelitis. Molecular Therapy — Methods & Clinical Development, 1, 14008. DOI:10.1038/mtm.2014.8 http://www.nature.com/articles/mtm20148

On, N. H., Kiptoo, P. Siahaan, T. J., & Miller, D. W. (2014). Modulation of blood-brain barrier permeability in mice using synthetic E-cadherin peptide. Molecular Pharmaceutics, 11(3), 974–981. DOI:10.1021/mp400624v http://pubs.acs.org/doi/abs/10.1021/mp400624v

Chittasupho, C. Sestak, J. Shannon, L. Siahaan, T. J., Vines, C. M., & Berkland, C. (2014). Hyaluronic acid graft polymers displaying peptide antigen modulate dendritic cell response in vitro. Mol. Pharm., 11(1), 367–373. DOI:10.1021/mp4003909 http://pubs.acs.org/doi/abs/10.1021/mp4003909

Badawi, A. H., & Siahaan, T. J. (2013). Suppression of MOG- and PLP-induced experimental autoimmune encephalomyelitis using a novel multivalent bifunctional peptide inhibitor. J. Neuroimmunol., 263(1-2), 20–27. DOI:10.1016/j.jneuroim.2013.07.009 http://www.jni-journal.com/article/S0165-5728(13)00182-3/abstract

Sestak, J. Mullins, M. Northrup, L. Thati, S. Forrest, M. L., Siahaan, T. J., & Berkland, C. (2013). Single-step grafting of aminooxy-peptides to hyaluronan: a simple approach to multifunctional therapeutics for experimental autoimmune encephalomyelitis. J. Control. Rel., 168(3), 334–340. DOI:10.1016/j.jconrel.2013.03.015 http://www.sciencedirect.com/science/article/pii/S0168365913001582 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672265/

Kiptoo, P. Büyüktimkin, B. Badawi, A. H., Stewart, J. Ridwan, R. & Siahaan, T. J. (2013). Controlling immune response and demyelination using highly potent bifunctional peptide inhibitors in the suppression of experimental autoimmune encephalomyelitis. Clin. Exp. Immunol., 172(1), 23–36. DOI:10.1111/cei.12029 http://onlinelibrary.wiley.com/doi/10.1111/cei.12029/abstract

Phongpradist, R. Chittasupho, C. Intasai, N. Siahaan, T. J., Berkland, C. J., Charoenkwan, P. Anuchapreeda, S. & Ampasavate, C. (2013). Biodegradable nanoparticles surface modification techniques with cIBR peptide targeting to LFA-1 expressing leukemic cells. J. Nanotechnol. Eng. Med., 3(4), 041005-1-9. DOI:10.1115/1.4023896 http://nanoengineeringmedical.asmedigitalcollection.asme.org/article.aspx?articleID=1679493

Büyüktimkin, B. Manikwar, P. Kiptoo, P. K., Badawi, A. H., Stewart, J. M., & Siahaan, T. J. (2013). Vaccinelike and prophylactic treatments of EAE with novel I-domain antigen conjugates (IDAC): targeting multiple antigenic peptides to APC. Mol. Pharm., 10(1), 297–306. DOI:10.1021/mp300440x http://pubs.acs.org/doi/abs/10.1021/mp300440x

Phongpradist, R. Chiampanichayakul, S. Tima, S. Siahaan, T. J., Berkland, C. J., Anuchapreeda, S. & Ampasavate, C. (2012). Potential cIBR-conjugated PLGA nanoparticles for selective targeting to leukemic cells. World Acad. of Sci., Eng. Tech., 66, 202–210. http://waset.org/publications/6057/potential-cibr-conjugated-plga-nanoparticles-for-selective-targeting-to-leukemic-cells

Majumdar, S. Anderson, M. E., Xu, C. R., Yakovleva, T. V., Gu, L. C., Malefyt, T. R., & Siahaan, T. J. (2012). Methotrexate (MTX)-cIBR conjugate for targeting MTX to leukocytes: conjugate stability and in vivo efficacy in suppressing rheumatoid arthritis. Journal of Pharmaceutical Sciences, 101(9), 3275-91. DOI:10.1002/jps.23164 http://jpharmsci.org/article/S0022-3549(15)31442-8/abstract https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474090/

Badawi, A. H., & Siahaan, T. J. (2012). Immune modulating peptides for the treatment and suppression of multiple sclerosis. Clin. Immunol., 144(2), 127–38. DOI:10.1016/j.clim.2012.05.010 http://www.sciencedirect.com/science/article/pii/S1521661612001465 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415220/

Trivedi, M. Laurence, J. S., Williams, T. D., Middaugh, C. R., & Siahaan, T. J. (2012). Improving the stability of the EC1 domain of E-cadherin by thiol alkylation of the cysteine residue. Int. J. Pharm., 431(1-2), 16–25. DOI:10.1016/j.ijpharm.2012.03.051 http://www.sciencedirect.com/science/article/pii/S0378517312003195 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358404/

Manikwar, P. Kiptoo, P. Badawi, A. H., Büyüktimkin, B. & Siahaan, T. J. (2012). Antigen-specific blocking of CD4-specific immunological synapse formation using BPI and current therapies for autoimmune diseases. Med. Res. Rev., 32(4), 727–764. DOI:10.1002/med.20243 http://onlinelibrary.wiley.com/doi/10.1002/med.20243/abstract

Majumdar, S. & Siahaan, T. J. (2012). Peptide-mediated targeted drug delivery. Med. Res. Rev., 32(3), 637–558. DOI:10.1002/med.20225 http://onlinelibrary.wiley.com/doi/10.1002/med.20225/abstract

Büyüktimkin, B. Wang, Q. Kiptoo, P. Stewart, J. M., Berkland, C. & Siahaan, T. J. (2012). Vaccine-like controlled-release delivery of an immunomodulating peptide to treat experimental autoimmune encephalomyelitis. Mol. Pharm., 9(4), 979–985. DOI:10.1021/mp200614q http://pubs.acs.org/doi/abs/10.1021/mp200614q

Manikwar, P. Büyüktimkin, B. Kiptoo, P. Badawi, A. H., Galeva, N. A., Williams, T. D., & Siahaan, T. J. (2012). I-domain-antigen conjugate (IDAC) for delivering antigenic peptides to APC: synthesis, characterization, and in vivo EAE suppression. Bioconjugate Chemistry, 23(3), 509–517. DOI:10.1021/bc200580j http://pubs.acs.org/doi/abs/10.1021/bc200580j

Badawi, A. H., Kiptoo, P. Wang, W. T., Choi, I. Y., Lee, P. Vines, C. M., & Siahaan, T. J. (2012). Suppression of EAE and prevention of blood-brain barrier breakdown after vaccination with novel bifunctional peptide inhibitor. Neuropharmacology, 62(4), 1874-81. DOI:10.1016/j.neuropharm.2011.12.013 http://www.sciencedirect.com/science/article/pii/S002839081100517X

Badawi, A. H., Büyüktimkin, B. Kiptoo, P. & Siahaan, T. J. (2011). Peptides and Proteins for Treatment and Suppression of Type 1 Diabetes. (Chapter 15). In D. Wagner (Ed.), Type 1 Diabetes - Pathogenesis, Genetics and Immunotherapy (pp. 339–354). InTech. http://www.intechopen.com/articles/show/title/peptides-and-proteins-for-treatment-and-suppression-of-type-1-diabetes

Manikwar, P. Zimmerman, T. Blanco, F. J., Williams, T. D., & Siahaan, T. J. (2011). Rapid identification of fluorochrome modification sites in proteins by LC ESI-Q-TOF mass spectrometry. Bioconjugate Chemistry, 22(7), 1330–13336. DOI:10.1021/bc100560c http://pubs.acs.org/doi/abs/10.1021/bc100560c

Chittasupho, C. Siahaan, T. J., Vines, C. M., & Berkland, C. (2011). Autoimmune therapies targeting costimulation and emerging trends in multivalent therapeutics. Therapeutic Delivery, 2(7), 873–889. DOI:10.4155/tde.11.60 http://www.future-science.com/doi/10.4155/tde.11.60 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186944/

Khondee, S. Baoum, A. Siahaan, T. J., & Berkland, C. (2011). Calcium condensed LABL-TAT complexes effectively target gene delivery to ICAM-1 expressing cells. Mol. Pharm., 8(3), 788–798. DOI:10.1021/mp100393j http://pubs.acs.org/doi/abs/10.1021/mp100393j

Chittasupho, C. Shannon, L. Siahaan, T. J., Vines, C. M., & Berkland, C. (2011). Nanoparticles targeting dendritic cell surface molecules effectively block T cell conjugation and shift response. ACS Nano, 5(3), 1693–702. DOI:10.1021/nn102159g http://pubs.acs.org/doi/abs/10.1021/nn102159g

Fakhari, A. Baoum, A. Siahaan, T. J., Le, K. B., & Berkland, C. (2011). Controlling ligand surface density optimizes nanoparticle binding to ICAM-1. J. Pharm. Sci., 100(3), 1045–1056. DOI:10.1002/jps.22342 http://onlinelibrary.wiley.com/doi/10.1002/jps.22342/abstract

Kiptoo, P. Sinaga, E. Calcagno, A. M., Zhao, H. Kobayashi, N. Tambunan, U. S., & Siahaan, T. J. (2011). Enhancement of drug absorption through the blood-brain barrier and inhibition of intercellular tight junction resealing by E-cadherin peptides. Mol. Pharm., 8(1), 239–249. DOI:10.1021/mp100293m http://pubs.acs.org/doi/abs/10.1021/mp100293m

Manikwar, P. Tejo, B. A., Shinogle, H. Moore, D. S., Zimmerman, T. Blanco, F. & Siahaan, T. J. (2011). Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes. Theranostics, 1, 277–289. DOI:10.7150/thno/v01p0277 http://www.thno.org/v01p0277.htm

Phongpradist, R. Chittasupho, C. Okonogi, S. Siahaan, T. J., Anuchapreeda, S. Amphasavate, C. & Berkland, C. (2010). LFA-1 on leukemic cells as a target for therapy or drug delivery. Curr. Pharm. Des., 16, 2321–2330 . DOI:10.2174/138161210791920450 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207650/pdf/nihms634172.pdf

Satyanarayanajois, S. D., Büyüktimkin, B. Gokhale, A. Ronald, S. Siahaan, T. J., & Latendresse, J. R. (2010). A peptide from the beta-strand region of CD2 protein that inhibits cell adhesion and suppresses arthritis in a mouse model. Chem. Biol. Drug Des., 76(3), 234–244. DOI:10.1111/j.1747-0285.2010.01001.x https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009390/pdf/nihms215240.pdf

Ridwan, R. Kiptoo, P. Kobayashi, N. Weir, S. Hughes, M. Williams, T. Soegianto, R. & Siahaan, T. J. (2010). Antigen-specific suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor: structure optimization and pharmacokinetics. J. Pharmacol. Exp. Ther., 332(3), 1136–1145. DOI:10.1124/jpet.109.161109 http://jpet.aspetjournals.org/content/early/2009/12/21/jpet.109.161109

Chittasupho, C. Manikwar, P. Krise, J. P., Siahaan, T. J., & Berkland, C. (2010). cIBR effectively targets nanoparticles to LFA-1 on acute lymphoblastic T cells. Molecular Pharmaceutics, 7(1), 146–155. DOI:10.1021/mp900185u http://pubs.acs.org/doi/abs/10.1021/mp900185u

Zhao, H. Kiptoo, P. Williams, T. D., Siahaan, T. J., & Topp, E. M. (2010). Immune response to controlled release of immunomodulating peptides in a murine experimental autoimmune encephalomyelitis (EAE) model. Journal of Controlled Release, 141(2), 145–152. DOI:10.1016/j.jconrel.2009.09.002 http://www.sciencedirect.com/science/article/pii/S016836590900618X

Trivedi, M. V., Laurence, J. S., & Siahaan, T. J. (2009). The role of thiols and disulfides on protein stability. Curr. Prot. Pept. Sci., 10(6), 614–625. DOI:10.2174/138920309789630534 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319691/

Trivedi, M. Davis, R. A., Shabaik, Y. Roy, A. Verkhivker, G. Laurence, J. S., Middaugh, C. R., & Siahaan, T. J. (2009). The role of covalent dimerization on the physical and chemical stability of the EC1 domain of human E-cadherin. J. Pharm. Sci., 98(10), 3562–3574. DOI:10.1002/jps.21686 http://www.jpharmsci.org/article/S0022-3549(16)33124-0/ppt

Williams, S. J., Wang, Q. Macgregor, R. R., Siahaan, T. J., Stehno-Bittel, L. & Berkland, C. (2009). Adhesion of pancreatic beta cells to biopolymer films. Biopolymers, 91(8), 676–685. DOI:10.1002/bip.21196 http://onlinelibrary.wiley.com/doi/10.1002/bip.21196/abstract

Tejo, B. A., & Siahaan, T. J. (2009). Solution structure of a novel T-cell adhesion inhibitor derived from the fragment of ICAM-1 receptor: cyclo(1,8)-Cys-Pro-Arg-Gly-Gly-Ser-Val-Cys. Biopolymers, 91(8), 633–641. DOI:10.1002/bip.21192 http://onlinelibrary.wiley.com/doi/10.1002/bip.21192/abstract

Zheng, K. Laurence, J. S., Kuczera, K. Verkhivker, G. Middaugh, C. R., & Siahaan, T. J. (2009). Characterization of multiple stable conformers of the EC5 domain of E-cadherin and the interaction of EC5 with E-cadherin peptides. Chem. Biol. Drug Des., 73(6), 584–598. DOI:10.1111/j.1747-0285.2009.00818.x http://onlinelibrary.wiley.com/doi/10.1111/j.1747-0285.2009.00818.x/abstract

Chittasupho, C. Xie, S. X., Baoum, A. Yakovleva, T. Siahaan, T. J., & Berkland, C. J. (2009). ICAM-1 targeting of doxorubicin-loaded PLGA nanoparticles to lung epithelial cells. Eur. J. Pharm. Sci., 37(2), 141–150. DOI:10.1016/j.ejps.2009.02.008 http://www.sciencedirect.com/science/article/pii/S0928098709000360

Majumdar, S. Tejo, B. A., Badawi, A. H., Moore, D. Krise, J. P., & Siahaan, T. J. (2009). Effect of modification of the physicochemical properties of ICAM-1-derived peptides on internalization and intracellular distribution in the human leukemic cell line HL-60. Mol. Pharm., 6(2), 396–406. DOI:10.1021/mp800120t http://pubs.acs.org/doi/abs/10.1021/mp800120t

Zheng, K. Middaugh, C. R., & Siahaan, T. J. (2009). Evaluation of the physical stability of the EC5 domain of E-cadherin: effects of pH, temperature, ionic strength, and disulfide bonds. J. Pharm. Sci., 98(1), 63–73. DOI:10.1002/jps.21418 http://jpharmsci.org/article/S0022-3549(16)32839-8/abstract

Kobayashi, N. Kiptoo, P. Kobayashi, H. Ridwan, R. Brocke, S. & Siahaan, T. J. (2008). Prophylactic and therapeutic suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor. Clin. Immunol., 129(1), 69–79. DOI:10.1016/j.clim.2008.06.002 http://www.sciencedirect.com/science/article/pii/S1521661608006840

Tejo, B. A., Tambunan, U. S., Verkhivker, G. & Siahaan, T. J. (2008). Structural modifications of ICAM-1 cyclic peptides to improve the activity to inhibit heterotypic adhesion of T cells. Chem. Biol. Drug Des., 72(1), 27–33. DOI:10.1111/j.1747-0285.2008.00676.x http://onlinelibrary.wiley.com/doi/10.1111/j.1747-0285.2008.00676.x/abstract

Zhang, N. Chittasupho, C. Duangrat, C. Siahaan, T. J., & Berkland, C. (2008). PLGA nanoparticle--peptide conjugate effectively targets intercellular cell-adhesion molecule-1. Bioconjugate Chemistry, 19(1), 145–152. DOI:10.1021/bc700227z http://pubs.acs.org/doi/abs/10.1021/bc700227z

Zimmerman, T. Oyarzabal, J. Sebastián, E. S., Majumdar, S. Tejo, B. A., Siahaan, T. J., & Blanco, F. J. (2007). ICAM-1 peptide inhibitors of T-cell adhesion bind to the allosteric site of LFA-1. An NMR characterization. Chem. Biol. Drug Des., 70(4), 347–353. DOI:10.1111/j.1399-3011.2007.00566.x http://onlinelibrary.wiley.com/doi/10.1111/j.1747-0285.2007.00566.x/full

Majumdar, S. Kobayashi, N. Krise, J. P., & Siahaan, T. J. (2007). Mechanism of internalization of an ICAM-1-derived peptide by human leukemic cell line HL-60: influence of physicochemical properties on targeted drug delivery. Molecular Pharmaceutics, 4(5), 749–758. DOI:10.1021/mp0700458 http://pubs.acs.org/doi/abs/10.1021/mp0700458

Yusuf-Makagiansar, H. Yakovleva, T. V., Tejo, B. A., Jones, K. Hu, Y. Verkhivker, G. M., Audus, K. L., & Siahaan, T. J. (2007). Sequence recognition of alpha-LFA-1-derived peptides by ICAM-1 cell receptors: inhibitors of T-cell adhesion. Chem. Biol. Drug Des., 70(3), 237–246. DOI:10.1111/j.1747-0285.2007.00549.x http://onlinelibrary.wiley.com/doi/10.1111/j.1747-0285.2007.00549.x/full

Murray, J. S., Oney, S. Page, J. E., Kratochvil-Stava, A. Hu, Y. Makagiansar, I. T., Brown, J. C., Kobayashi, N. & Siahaan, T. J. (2007). Suppression of type 1 diabetes in NOD mice by bifunctional peptide inhibitor: modulation of the immunological synapse formation. Chem. Biol. Drug Des., 70(3), 227–236. DOI:10.1111/j.1747-0285.2007.00552.x http://onlinelibrary.wiley.com/doi/10.1111/j.1747-0285.2007.00552.x/full

Kobayashi, N. Kobayashi, H. Gu, L. Malefyt, T. & Siahaan, T. J. (2007). Antigen-specific suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor. J. Pharmacol. Exp. Ther., 322(2), 879–886. DOI:10.1124/jpet.107.123257 http://jpet.aspetjournals.org/content/322/2/879

He, H. T., Gürsoy, R. N., Kupczyk-Subotkowska, L. Tian, J. Williams, T. D., & Siahaan, T. J. (2006). Synthesis and chemical stability of a disulfide bond in a model cyclic pentapeptide: cyclo(1,4)-Cys-Gly-Phe-Cys-Gly-OH. J. Pharm. Sci., 95(10), 2222–2234. DOI:10.1002/jps.20701 http://onlinelibrary.wiley.com/doi/10.1002/jps.20701/abstract

Dunehoo, A. L., Anderson, M. E., Majumdar, S. Kobayashi, N. Berkland, C. & Siahaan, T. J. (2006). Cell adhesion molecules for targeted drug delivery. J, 95(9), 1856–1872. DOI:10.1002/jps.20676 http://onlinelibrary.wiley.com/doi/10.1002/jps.20676/full

Anderson, M. E., Tejo, B. A., Yakovleva, T. & Siahaan, T. J. (2006). Characterization of binding properties of ICAM-1 peptides to LFA-1: inhibitors of T-cell adhesion. Chem. Biol. Drug Des., 68(1), 20–28. DOI:10.1111/j.1747-0285.2006.00407.x http://onlinelibrary.wiley.com/doi/10.1111/j.1747-0285.2006.00407.x/abstract

Kobayashi, N. Ikesue, A. Majumdar, S. & Siahaan, T. J. (2006). Inhibition of E-cadherin-mediated homotypic adhesion of Caco-2 cells: a novel evaluation assay for peptide activities in modulating cell-cell adhesion. J. Pharmacol. Exp. Ther., 317(1), 309–316. DOI:10.1124/jpet.105.097535 http://jpet.aspetjournals.org/content/317/1/309

Goebel, S. Huang, M. Davis, W. C., Jennings, M. Siahaan, T. J., Alexander, J. S., & Kevil, C. G. (2006). VEGF-A stimulation of leukocyte adhesion to colonic microvascular endothelium: implications for inflammatory bowel disease. Am. J. Physiol.: Gastrointest. Liver Physiol., 290(4), G648–654. DOI:10.1152/ajpgi.00466.2005 http://ajpgi.physiology.org/content/290/4/G648.long

Liederer, B. M., Fuchs, T. Vander Velde, D. Siahaan, T. J., & Borchardt, R. T. (2006). Effects of amino acid chirality and the chemical linker on the cell permeation characteristics of cyclic prodrugs of opioid peptides. J. Med. Chem., 49(4), 1261–1270. DOI:10.1021/jm050277f http://pubs.acs.org/doi/abs/10.1021/jm050277f

Zheng, K. Trivedi, M. & Siahaan, T. J. (2006). Structure and function of the intercellular junctions: barrier of paracellular drug delivery. Current Pharmaceutical Design, 12(22), 2813–2824. DOI:0.2174/138161206777947722 http://www.eurekaselect.com/56543/article

Wang, B., Siahaan, T. J., & Soltero, R. (Eds.). (2005). Drug Delivery: Principles and Applications (B. Wang, T. J. Siahaan, & R. Soltero, Eds.). New York: John Wiley & Sons. DOI:0.1002/0471475734

Krogmeier, S. L., Reddy, D. S., Vander Velde, D. Lushington, G. H., Siahaan, T. J., Middaugh, C. R., Borchardt, R. T., & Topp, E. M. (2005). Deamidation of model beta-turn cyclic peptides in the solid state. J. Pharm. Sci., 94(12), 2616–2631. DOI:10.1002/jps.20468 http://onlinelibrary.wiley.com/doi/10.1002/jps.20468/abstract

Calcagno, A. M., Fostel, J. M., Orchekowski, R. P., Alston, J. T., Mattes, W. B., Siahaan, T. J., & Ware, J. A. (2005). Modulation of cell adhesion molecules in various epithelial cell lines after treatment with PP2. Molecular Pharmaceutics, 2(3), 170-84. DOI:10.1021/mp0499003 http://pubs.acs.org/doi/abs/10.1021/mp0499003

Huang, M. Matthews, K. Siahaan, T. J., & Kevil, C. G. (2005). Alpha L-integrin I domain cyclic peptide antagonist selectively inhibits T cell adhesion to pancreatic islet microvascular endothelium. Am. J. Physiol.: Gastrointest. Liver Physiol., 288(1), G67–73. DOI:10.1152/ajpgi.00267.2004 http://ajpgi.physiology.org/content/288/1/G67

Calcagno, A. M., Fostel, J. M., Reyner, E. L., Sinaga, E. Alston, J. T., Mattes, W. B., Siahaan, T. J., & Ware, J. A. (2004). Effects of an E-cadherin-derived peptide on the gene expression of Caco-2 cells. Pharm. Res., 21(11), 2085–2094. DOI:10.1023/B:PHAM.0000048201.00143.72 http://link.springer.com/article/10.1023/B%3APHAM.0000048201.00143.72

Jining, L. Makagiansar, I. T., Yusuf-Makagiansar, H. Chow, V. T., Siahaan, T. J., & Jois, S. D. (2004). Design, structure and biological activity of beta-turn peptides of CD2 protein for inhibition of T-cell adhesion. Eur. J. Biochem., 271(14), 2873–2886. DOI:10.1111/j.1432-1033.2004.04198.x http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1432-1033.2004.04198.x/full

Rahman, R. N., Tejo, B. A., Basri, M. Rahman, M. B., Khan, F. Zain, S. M., Siahaan, T. J., & Salleh, A. B. (2004). Reductive alkylation of lipase: experimental and molecular modeling approaches. Appl. Biochem. Biotech., 118(1-3), 11–20. DOI:10.1385/ABAB:118:1-3:011 http://link.springer.com/article/10.1385/ABAB%3A118%3A1-3%3A011

Stotz, C. E., Borchardt, R. T., Middaugh, C. R., Siahaan, T. J., Vander Velde, D. & Topp, E. M. (2004). Secondary structure of a dynamic type I'beta-hairpin peptide. Journal of Peptide Research, 63(4), 371–382. DOI:10.1111/j.1399-3011.2004.00129.x http://onlinelibrary.wiley.com/doi/10.1111/j.1399-3011.2004.00129.x/abstract

Anderson, M. E., Yakovleva, T. Hu, Y. & Siahaan, T. J. (2004). Inhibition of ICAM-1/LFA-1-mediated heterotypic T-cell adhesion to epithelial cells: Design of ICAM-1 cyclic peptides. Bioorg. Med. Chem. Lett., 14(6), 1399–1402. DOI:10.1016/j.bmcl.2003.09.100 http://www.sciencedirect.com/science/article/pii/S0960894X04000605

Zheng, K. Makagiansar, I. T., Wang, M. Urbauer, J. L., Kuczera, K. & Siahaan, T. J. (2004). Expression, purification, and structural study of the EC4 domain of E-cadherin. Prot. Express. Purif., 33(1), 72–79. DOI:10.1016/j.pep.2003.08.021 http://www.sciencedirect.com/science/article/pii/S1046592803002894

Jois, S. S., & Siahaan, T. J. (2003). A peptide derived from LFA-1 that modulates T-cell adhesion binds to soluble ICAM-1 protein. J. Biomol. Str. Dyn., 20, 635-644. DOI:10.1080/07391102.2003.10506880 http://www.tandfonline.com/doi/abs/10.1080/07391102.2003.10506880

Xu, C. R., He, H. T., Song, X. & Siahaan, T. J. (2003). Synthesis and comparison of physicochemical, transport and antithrombic properties of a cyclic prodrug and the parent RGD peptidomimetic. Tetrahedron, 59, 2861–2869. DOI:10.1016/S0040-4020(03)00333-8 http://www.sciencedirect.com/science/article/pii/S0040402003003338

Anderson, M. E., & Siahaan, T. J. (2003). Mechanism of binding and internalization of ICAM-1-derived cyclic peptides by LFA-1 on the surface of T cells: a potential method for targeted drug delivery. Pharm. Res., 20(10), 1523–1532. DOI:10.1023/A:1026188212126 http://link.springer.com/article/10.1023/A%3A1026188212126

Shuxing, Z. Ying, W. S., Siahaan, T. J., & Jois, S. D. (2003). Solution structure of a peptide derived from the beta subunit of LFA-1. Peptides, 24(6), 827-35. DOI:10.1016/S0196-9781(03)00170-0 http://www.sciencedirect.com/science/article/pii/S0196978103001700?np=y

He, H. T., Xu, C. R., Song, X. & Siahaan, T. J. (2003). Syntheses of cyclic prodrugs of RGD peptidomimetics with various macrocyclic ring sizes: evaluation of physicochemical, transport and antithrombic properties. Journal of Peptide Research, 61(6), 331–342. DOI:10.1034/j.1399-3011.2003.00062.x http://onlinelibrary.wiley.com/doi/10.1034/j.1399-3011.2003.00062.x/abstract

Anderson, M. E., & Siahaan, T. J. (2003). Targeting ICAM-1/LFA-1 interaction for controlling autoimmune diseases: designing peptide and small molecule inhibitors. Peptides, 24(3), 487–501. DOI:10.1016/S0196-9781(03)00083-4 http://www.sciencedirect.com/science/article/pii/S0196978103000834

Makagiansar, I. T., Ikesue, A. Nguyen, P. D., Urbauer, J. L., Bieber-Urbauer, R. J., & Siahaan, T. J. (2002). Localized production of human E-cadherin-derived first repeat in Escherichia coli. Protein Expr. Purif., 26(3), 449–454. DOI:10.1016/S1046-5928(02)00553-3

Mahadevan, J. Xu, R. Siahaan, T. J., & Kuczera, K. (2002). Molecular dynamics simulations of conformational behavior of linear RGD peptidomimetics and cyclic prodrugs in aqueous and octane solutions. J. Biomol. Struc. Dyn., 19, 775–788. DOI:10.1080/07391102.2002.10506784 http://www.tandfonline.com/doi/abs/10.1080/07391102.2002.10506784

Ouyang, H. Borchardt, R. T., & Siahaan, T. J. (2002). Steric hindrance is a key factor in the coupling reaction of (acyloxy)alkyl-α-halides with phenols to make a new promoiety for prodrugs. Tetrahedron Lett., 43, 577-579. DOI:10.1016/S0040-4039(01)02241-9 http://www.sciencedirect.com/science/article/pii/S0040403901022419

Song, X. & Siahaan, T. J. (2002). Synthesis and stability study of a modified phenylpropionic acid linker-based esterase-sensitive prodrug. Bioorg. Med. Chem. Lett., 12(23), 3439–3442. DOI:10.1016/S0960-894X(02)00750-3 http://www.sciencedirect.com/science/article/pii/S0960894X02007503

Makagiansar, I. T., Ikesue, A. Nguyen, P. D., Urbauer, J. L., Urbauer, R. J., & Siahaan, T. J. (2002). Localized production of human E-cadherin-derived first repeat in Escherichia coli. Prot. Express. Purif., 26(3), 449–454. DOI:10.1016/S1046-5928(02)00553-3 http://www.sciencedirect.com/science/article/pii/S1046592802005533

Sinaga, E. Jois, S. D., Avery, M. Makagiansar, I. T., Tambunan, U. S., Audus, K. L., & Siahaan, T. J. (2002). Increasing paracellular porosity by E-cadherin peptides: discovery of bulge and groove regions in the EC1-domain of E-cadherin. Pharm. Res., 19(8), 1170–1179. DOI:10.1023/A:1019850226631 http://link.springer.com/article/10.1023/A%3A1019850226631

Song, X. Xu, C. R., He, H. T., & Siahaan, T. J. (2002). Synthesis of a novel cyclic prodrug of RGD peptidomimetic to improve its cell membrane permeation. Bioorganic Chemistry, 30(4), 285–301. DOI:10.1016/S0045-2068(02)00013-5 http://www.sciencedirect.com/science/article/pii/S0045206802000135

Ouyang, H. Tang, F. Siahaan, T. J., & Borchardt, R. T. (2002). A modified coumarinic acid-based cyclic prodrug of an opioid peptide: its enzymatic and chemical stability and cell permeation characteristics. Pharm. Res., 19(6), 794–801. DOI:10.1023/A:1016148631055 http://link.springer.com/article/10.1023/A%3A1016148631055

Makagiansar, I. T., Nguyen, P. D., Ikesue, A. Kuczera, K. Dentler, W. Urbauer, J. L., Galeva, N. Alterman, M. & Siahaan, T. J. (2002). Disulfide bond formation promotes the cis- and trans-dimerization of the E-cadherin-derived first repeat. J. Biol. Chem., 277(18), 16002–16010. DOI:10.1074/jbc.M200916200 http://www.jbc.org/content/277/18/16002.full

Makagiansar, I. T., Yusuf-Makagiansar, H. Ikesue, A. Calcagno, A. M., Murray, J. S., & Siahaan, T. J. (2002). N-cadherin involvement in the heterotypic adherence of malignant T-cells to epithelia. Molecular and Cellular Biochemistry, 233(1-2), 1–8. DOI:10.1023/A:1015556625038 http://link.springer.com/article/10.1023/A%3A1015556625038

Xu, C. R., Yusuf-Makagiansar, H. Hu, Y. Jois, S. D., & Siahaan, T. J. (2002). Structural and ICAM-1-docking properties of a cyclic peptide from the I-domain of LFA-1: an inhibitor of ICAM-1/LFA- 1-mediated T-cell adhesion. J. Biomol. Struct. Dyn., 19(5), 789–799. DOI:10.1080/07391102.2002.10506785 http://www.tandfonline.com/doi/full/10.1080/07391102.2002.10506785

Ouyang, H. Vander Velde, D. G., Borchardt, R. T., & Siahaan, T. J. (2002). Synthesis and conformational analysis of a coumarinic acid-based cyclic prodrug of an opioid peptide with modified sensitivity to esterase-catalyzed bioconversion. Journal of Peptide Research, 59(4), 183–95. DOI:0.1034/j.1399-3011.2002.1o983.x http://onlinelibrary.wiley.com/doi/10.1034/j.1399-3011.2002.1o983.x/abstract

Hu, Y. Webb, E. Singh, J. Morgan, B. A., Gainor, J. A., Gordon, T. D., & Siahaan, T. J. (2002). Rapid determination of substrate specificity of Clostridium histolyticum beta-collagenase using an immobilized peptide library. J. Biol. Chem., 277(10), 8366–8371. DOI:10.1074/jbc.M111042200 http://www.jbc.org/content/277/10/8366.long

Yusuf-Makagiansar, H. Anderson, M. E., Yakovleva, T. V., Murray, J. S., & Siahaan, T. J. (2002). Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases. Medicinal Research Reviews, 22(2), 146–167. DOI:10.1002/med.10001 http://onlinelibrary.wiley.com/doi/10.1002/med.10001/abstract

Murray, J. S., Fois, S. D., Schountz, T. Ford, S. R., Tawde, M. D., Brown, J. C., & Siahaan, T. J. (2002). Modeling alternative binding registers of a minimal immunogenic peptide on two class II major histocompatibility complex (MHC II) molecules predicts polarized T-cell receptor (TCR) contact positions. Journal of Peptide Research, 59(3), 115–22. DOI:10.1034/j.1399-3011.2002.01960.x http://onlinelibrary.wiley.com/doi/10.1034/j.1399-3011.2002.01960.x/abstract

Song, X. He, H. T., & Siahaan, T. J. (2002). Synthesis of cyclic prodrugs of Aggrastat and its analogue with a modified phenylpropionic acid linker. Organic Letters, 4(4), 549–552. DOI:10.1021/ol010282n http://pubs.acs.org/doi/abs/10.1021/ol010282n

Sakaeda, T. Tada, Y. Sugawara, T. Ryu, T. Hirose, F. Yoshikawa, T. Hirano, K. Kupczyk-Subotkowska, L. Siahaan, T. J., Audus, K. L., & Stella, V. J. (2001). Conjugation with L-Glutamate for in vivo brain drug delivery. J. Drug. Target., 9(1), 23–37. DOI:0.3109/10611860108995630 http://www.tandfonline.com/doi/abs/10.3109/10611860108995630?journalCode=idrt20

Yusuf-Makagiansar, H. Makagiansar, I. T., Hu, Y. & Siahaan, T. J. (2001). Synergistic inhibitory activity of alpha- and beta-LFA-1 peptides on LFA-1/ICAM-1 interaction. Peptides, 22(12), 1955–1962. DOI:10.1016/S0196-9781(01)00546-0 http://www.sciencedirect.com/science/article/pii/S0196978101005460

Hamilton, K. O., Topp, E. Makagiansar, I. T., Siahaan, T. J., Yazdanian, M. & Audus, K. L. (2001). Multidrug resistance associated protein-1 (MRP-1) functional activity in Calu-3 cells. Pharmacol. Exp. Ther., 298, 1199–1205. http://jpet.aspetjournals.org/content/298/3/1199.long

Yusuf-Makagiansar, H. Makagiansar, I. T., & Siahaan, T. J. (2001). Inhibition of the adherence of T-lymphocytes to epithelial cells by a cyclic peptide derived from inserted domain of lymphocyte function-associated antigen-1. Inflammation, 25(3), 203–214. DOI:10.1023/A:1011044616170 http://link.springer.com/article/10.1023/A:1011044616170

Makagiansar, I. T., Avery, M. Hu, Y. Audus, K. L., & Siahaan, T. J. (2001). Improving the selectivity of HAV-peptides in modulating E-cadherin-E-cadherin interactions in the intercellular junction of MDCK cell monolayers. Pharm. Res., 18(4), 446–453. DOI:10.1023/A:1011094025008 http://link.springer.com/article/10.1023/A%3A1011094025008

Yusuf-Makagiansar, H. & Siahaan, T. J. (2001). Binding and internalization of an LFA-1-derived cyclic peptide by ICAM receptors on activated lymphocyte: a potential ligand for drug targeting to ICAM-1-expressing cells. Pharm. Res., 18(3), 329–335. DOI:10.1023/A:1011007014510 http://link.springer.com/article/10.1023/A:1011007014510

Sakaeda, T. Tada, Y. Sugawara, T. Ryu, T. Hirose, F. Yoshikawa, T. Hirano, K. Kupczyk-Subotkowska, L. Siahaan, T. J., Audus, K. L., & Stella, V. J. (2001). Conjugation with L-Glutamate for in vivo brain drug delivery. J. Drug Targeting, 9(1), 23–37. DOI:10.3109/10611860108995630 http://dx.doi.org/10.3109/10611860108995630

Tibbetts, S. A., Jois, S. D., Siahaan, T. J., Benedict, S. H., & Chan, M. A. (2000). Linear and cyclic LFA-1 and ICAM-1 peptides inhibit T cell adhesion and function. Peptides, 21(8), 1161-1167. DOI:10.1016/S0196-9781(00)00255-2 http://www.sciencedirect.com/science/article/pii/S0196978100002552

Antipas, A. S., Vander Velde, D. G., Jois, S. S., Siahaan, T. J., & Stella, V. J. (2000). Effect of conformation on the rate of deamidation of Vancomycin in aqueous solutions. J. Pharm. Sci., 89, 742–750. DOI:10.1002/(SICI)1520-6017(200006)89:63.0.CO;2-9 http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291520-6017%28200006%2989:6%3C742::AID-JPS5%3E3.0.CO;2-9/abstract

Sakaeda, T. Siahaan, T. J., Audus, K. L., & Stella, V. J. (2000). Enhancement of transport of D-melphalan analogue by conjugation with L-glutamate across bovine brain microvessel endothelial cell monolayers. J. Drug Target., 8(3), 195–204. DOI:10.3109/10611860008996865 http://www.tandfonline.com/doi/abs/10.3109/10611860008996865

Gudmundsson, O. S., Nimkar, K. Gangwar, S. Siahaan, T. J., & Borchardt, R. T. (1999). Phenylpropionic acid-based cyclic products of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeation. Pharm. Res., 16, 16–23. DOI:10.1023/A:1018802324759 http://link.springer.com/article/10.1023/A:1018802324759

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Tibbetts, S. A., Chirathaworn, C. Nakashima, M. Jois, S. D., Siahaan, T. J., Chan, M. A., & Benedict, S. H. (1999). Peptides derived from ICAM-1 and LFA-1 modulate T cell adhesion and immune function in a mixed lymphocyte culture. Transplantation, 68(5), 685–692. http://journals.lww.com/transplantjournal/Abstract/1999/09150/PEPTIDES_DERIVED_FROM_ICAM_1_AND_LFA_1_MODULATE_T.15.aspx

Bogdanowich-Knipp, S. J., Jois, S. D., & Siahaan, T. J. (1999). Effect of conformation on the conversion of cyclo-(1,7)-Gly-Arg-Gly-Asp-Ser-Pro-Asp-Gly-OH to its cyclic imide degradation product. Journal of Peptide Research, 54(1), 43–53. DOI:10.1034/j.1399-3011.1999.00091.x http://onlinelibrary.wiley.com/doi/10.1034/j.1399-3011.1999.00091.x/abstract

Bogdanowich-Knipp, S. J., Chakrabarti, S. Williams, T. D., Dillman, R. K., & Siahaan, T. J. (1999). Solution stability of linear vs. cyclic RGD peptides. Journal of Peptide Research, 53(5), 530–541. DOI:10.1034/j.1399-3011.1999.00052.x http://onlinelibrary.wiley.com/doi/10.1034/j.1399-3011.1999.00052.x/abstract

Bogdanowich-Knipp, S. J., Jois, S. D., & Siahaan, T. J. (1999). The effect of conformation on the solution stability of linear vs. cyclic RGD peptides. Journal of Peptide Research, 53(5), 523–529. DOI:10.1034/j.1399-3011.1999.00055.x http://onlinelibrary.wiley.com/doi/10.1034/j.1399-3011.1999.00055.x/abstract

Gürsoy, R. N., & Siahaan, T. J. (1999). Binding and internalization of an ICAM-1 peptide by the surface receptors of T cells. Journal of Peptide Research, 53(4), 414–421. DOI:10.1034/j.1399-3011.1999.00079.x http://onlinelibrary.wiley.com/doi/10.1034/j.1399-3011.1999.00079.x/abstract

Gürsoy, R. N., Jois, S. D., & Siahaan, T. J. (1999). Structural recognition of an ICAM-1 peptide by its receptor on the surface of T cells: conformational studies of cyclo (1, 12)-Pen-Pro-Arg-Gly-Gly-Ser-Val-Leu-Val-Thr-Gly-Cys-OH. Journal of Peptide Research, 53(4), 422–431. DOI:10.1034/j.1399-3011.1999.00080.x http://onlinelibrary.wiley.com/doi/10.1034/j.1399-3011.1999.00080.x/abstract

Bak, A. Siahaan, T. J., Gudmundsson, O. S., Gangwar, S. Friis, G. J., & Borchardt, R. T. (1999). Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using an (acyloxy)alkoxy linker. Journal of Peptide Research, 53(4), 393–402. DOI:10.1034/j.1399-3011.1999.00070.x http://onlinelibrary.wiley.com/doi/10.1034/j.1399-3011.1999.00070.x/full

Gudmundsson, O. S., Vander Velde, D. G., Jois, S. D., Bak, A. Siahaan, T. J., & Borchardt, R. T. (1999). The effect of conformation of the acyloxyalkoxy-based cyclic prodrugs of opioid peptides on their membrane permeability. Journal of Peptide Research, 53(4), 403–413. DOI:10.1034/j.1399-3011.1999.00077.x http://onlinelibrary.wiley.com/doi/10.1034/j.1399-3011.1999.00077.x/abstract

Gudmundsson, O. S., Jois, S. D., Vander Velde, D. G., Siahaan, T. J., Wang, B. & Borchardt, R. T. (1999). The effect of conformation on the membrane permeation of coumarinic acid- and phenylpropionic acid-based cyclic prodrugs of opioid peptides. Journal of Peptide Research, 53(4), 383–392. DOI:10.1034/j.1399-3011.1999.00077.x http://onlinelibrary.wiley.com/doi/10.1034/j.1399-3011.1999.00077.x/abstract

Jois, S. D., Tibbetts, S. A., Chan, M. A., Benedict, S. H., & Siahaan, T. J. (1999). A Ca2+ binding cyclic peptide derived from the alpha-subunit of LFA-1: inhibitor of ICAM-1/LFA-1-mediated T-cell adhesion. Journal of Peptide Research, 53(1), 18–29. DOI:10.1111/j.1399-3011.1999.tb01613.x onlinelibrary.wiley.com/doi/10.1111/j.1399-3011.1999.tb01613.x/full

Bak, A. Gudmundsson, O. S., Friis, G. J., Siahaan, T. J., & Borchardt, R. T. (1999). Acyloxyalkoxy-based cyclic prodrugs of opioid peptides: evaluation of the chemical and enzymatic stability as well as their transport properties across Caco-2 cell monolayers. Pharm. Res., 16(1), 24–29. DOI:10.1023/A:1018854308829 http://link.springer.com/article/10.1023/A%3A1018854308829

Gangwar, S. Pauletti, G. M., Siahaan, T. J., Stella, V. J., & Borchardt, R. T. (1999). Synthesis of an esterase-sensitive cyclic prodrug of a model hexapeptide having enhanced membrane permeability and enzymatic stability using an acyloxyalkoxy promoiety. Meth. Mol. Med., 23, 37–51. DOI:10.1385/0-89603-517-4:37

Gangwar, S. Pauletti, G. M., Wang, B. Siahaan, T. J., Stella, V. J., & Borchardt, R. T. (1997). Prodrug strategies to enhance the intestinal absorption of peptides. Drug Discovery Today, 2, 148–155. DOI:10.1016/S1359-6446(97)01011-8 http://www.sciencedirect.com/science/article/pii/S1359644697010118

Kupczyk-Subotkowska, L. Tamura, K. Pal, D. Sakaeda, T. Siahaan, T. J., Stella, V. J., & Borchardt, R. T. (1997). Derivatives of melphalan designed to enhance drug accumulation in cancer cells. J. Drug Targeting, 4(6), 359–370. DOI:10.3109/10611869709017893 http://www.tandfonline.com/doi/abs/10.3109/10611869709017893

Knipp, G. T., Vander Velde, D. G., Siahaan, T. J., & Borchardt, R. T. (1997). The effect of beta-turn structure on the passive diffusion of peptides across Caco-2 cell monolayers. Pharm. Res., 14(10), 1332–1340. DOI:10.1023/A:1012152117703 http://link.springer.com/article/10.1023/A%3A1012152117703

Lutz, K. L., & Siahaan, T. J. (1997). Molecular structure of the apical junction complex and its contribution to the paracellular barrier. J. Pharm. Sci., 86(9), 977–984. DOI:10.1021/js970134j http://onlinelibrary.wiley.com/doi/10.1021/js970134j/abstract

Pauletti, G. M., Gangwar, S. Siahaan, T. J., Aube, J. & Borchardt, R. T. (1997). Improvement of oral peptide bioavailability: Peptide mimetics and prodrug strategies. Adv. Drug Del. Rev., 27, 235–256.

Pauletti, G. M., Gangwar, S. Siahaan, T. J., Aubé, J. & Borchardt, R. (1997). Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies. Adv. Drug Del. Rev., 27(2-3), 235–256. DOI:10.1016/S0169-409X(97)00045-8 http://www.sciencedirect.com/science/article/pii/S0169409X97000458

Hühmer, A. F., Aced, G. I., Perkins, M. D., Gürsoy, R. N., Jois, D. S., Larive, C. Siahaan, T. J., & Schôneich, C. (1997). Separation and analysis of peptides and proteins. Analytical Chemistry, 69(12), 29R–57R. DOI:10.1021/a1970003s http://pubs.acs.org/doi/abs/10.1021/a1970003s

Jois, D. S., Pal, D. Tibbetts, S. A., Chan, M. A., Benedict, S. H., & Siahaan, T. J. (1997). Inhibition of homotypic adhesion of T-cells: secondary structure of an ICAM-1-derived cyclic peptide. Journal of Peptide Research, 49(6), 517–526. DOI:10.1111/j.1399-3011.1997.tb01159.x http://onlinelibrary.wiley.com/doi/10.1111/j.1399-3011.1997.tb01159.x/abstract

Kupczyk-Subotkowska, L. Siahaan, T. J., Basile, A. S., Friedman, H. S., Higgins, P. E., Song, D. & Gallo, J. M. (1997). Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate. J. Med. Chem., 40(11), 1726–1730. DOI:10.1021/jm960592p http://pubs.acs.org/doi/abs/10.1021/jm960592p

Lutz, K. L., & Siahaan, T. J. (1997). Modulation of the cellular junctions protein E-cadherin in bovine brain microvessel endothelial cells by cadherin peptides. Drug Delivery, 10, 187–193. DOI:10.3109/10717549709051891 http://www.tandfonline.com/doi/abs/10.3109/10717549709051891

Gangwar, S. Pauletti, G. M., Siahaan, T. J., Stella, V. J., & Borchardt, R. T. (1997). Synthesis of a novel esterase-sensitive cyclic prodrug of a hexapeptide using an acyloxyalkoxy promoiety. J. Org. Chem., 62, 1356–1362. DOI:10.1021/jo961696a http://pubs.acs.org/doi/abs/10.1021/jo961696a

Wang, B. Gangwar, S. Pauletti, G. M., Siahaan, T. J., & Borchardt, R. T. (1997). Synthesis of a novel esterase-sensitive cyclic prodrug system for peptides that utilizes a "trimethyl lock"-facilitated lactonization reaction. J. Org. Chem., 62, 1363–1367. DOI:10.1021/jo961778z http://pubs.acs.org/doi/abs/10.1021/jo961778z

Okumu, F. W., Pauletti, G. M., Vander Velde, D. G., Siahaan, T. J., & Borchardt, R. T. (1997). Effect of restricted conformational flexibility on the permeation of model hexapeptides across Caco-2 cell monolayers. Pharm. Res., 14(2), 169–175. DOI:10.1023/A:1012092409216 http://link.springer.com/article/10.1023/A%3A1012092409216

Pal, D. J., Audus, K. L., & Siahaan, T. J. (1997). Modulation of cellular adhesion in bovine brain microvessel endothelial cells by a decapeptide. Brain Research, 747(1), 103–113. DOI:10.1016/S0006-8993(96)01223-1 http://www.sciencedirect.com/science/article/pii/S0006899396012231

Jois, D. S., Conrad, M. W., Chakrabarti, S. & Siahaan, T. J. (1997). Conformational analysis of cyclo(2,9)-Ac-QCRSVEGSCG-OH from the C-terminal loop of human growth hormone. The journal of peptide research : official journal of the American Peptide Society, 49(1), 15-22. DOI:10.1111/j.1399-3011.1997.tb01116.x http://onlinelibrary.wiley.com/doi/10.1111/j.1399-3011.1997.tb01116.x/abstract http://onlinelibrary.wiley.com/doi/10.1111/j.1399-3011.1997.tb01116.x/pdf

Pauletti, G. M., Gangwar, S. Okumu, F. W., Siahaan, T. J., Stella, V. J., & Borchardt, R. T. (1996). Esterase-sensitive cyclic prodrugs of peptides: evaluation of an acyloxyalkoxy promoiety in a model hexapeptide. Pharm. Res., 13(11), 1615–1623. DOI:10.1023/A:1016472119387 http://link.springer.com/article/10.1023/A:1016472119387

Gangwar, S. Jois, S. D., Siahaan, T. J., Vander Velde, D. G., Stella, V. J., & Borchardt, R. T. (1996). The effect of conformation on membrane permeability of an acyloxyalkoxy-linked cyclic prodrug of a model hexapeptide. Pharm. Res., 13(11), 1657–1662. DOI:10.1023/A:1016484522113 http://link.springer.com/article/10.1023/A:1016484522113

Lutz, K. L., Szabo, L. A., Thompson, D. L., & Siahaan, T. J. (1996). Antibody recognition of peptide sequences from the cell-cell adhesion proteins: N- and E-cadherins. Peptide Research, 9(5), 233–239. http://www.pubfacts.com/detail/9000249/Antibody-recognition-of-peptide-sequences-from-the-cell-cell-adhesion-proteins-N-and-E-cadherins

Pauletti, G. M., Gangwar, S. Knipp, G. T., Nerurkar, M. M., Okumu, F. W., Tamura, K. Siahaan, T. J., & Borchardt, R. T. (1996). Structural requirements for intestinal absorption of peptide drugs. J. Control. Rel., 41, 3–17. DOI:10.1016/0168-3659(96)01352-1 http://www.sciencedirect.com/science/article/pii/0168365996013521

Jois, S. D., Tambunan, U. S., Chakrabarti, S. & Siahaan, T. J. (1996). Solution structure of a cyclic RGD peptide that inhibits platelet aggregation. J. Biomol. Struct. Dyn., 14(1), 1–11. DOI:10.1080/07391102.1996.10508923 http://www.tandfonline.com/doi/abs/10.1080/07391102.1996.10508923

Lutz, K. L., Jois, S. D., & Siahaan, T. J. (1995). Secondary structure of the HAV peptide which regulates cadherin-cadherin interaction. J. Biomol. Struct. Dyn., 13(3), 447–455. DOI:10.1080/07391102.1995.10508854 http://www.tandfonline.com/doi/abs/10.1080/07391102.1995.10508854

Schöneich, C. Hühmer, A. R., Rabel, S. R., Stobaugh, J. F., Jois, S. S., Larive, C. K., Siahaan, T. J., Squier, T. C., Bigelow, D. J., & Williams, T. D. (1995). Separation and analysis of peptides and proteins. Anal. Chem., 67, 155R–181R. DOI:10.1021/ac00108a009 ubs.acs.org/doi/pdf/10.1021/ac00108a009

Lutz, K. L., & Siahaan, T. J. (1995). E-cadherin peptide sequence recognition by anti-E-cadherin antibody. Biochem. Biophys. Res. Commun., 211(1), 21–27. DOI:10.1006/bbrc.1995.1772 http://www.sciencedirect.com/science/article/pii/S0006291X8571772X

Oliyai, R. Siahaan, T. J., & Stella, V. J. (1995). The importance of structural factors on the rate and the extent of N,O-acyl migration in cyclic and linear peptides. Pharm. Res., 12(3), 323–328. DOI:10.1023/A:1016231913858 http://link.springer.com/article/10.1023/A:1016231913858

Siahaan, T. J., Bruss, D. Powell, N. A., Chakrabarti, S. & Conrad, M. (1994). The aqueous conformation of cyclo(1,6)Ac-Cys-Arg-Gly-Asp-Phe-Pen-NH2. Int. J. Pept. Prot. Res., 44(5), 427–434. DOI:10.1111/j.1399-3011.1994.tb00178.x http://onlinelibrary.wiley.com/doi/10.1111/j.1399-3011.1994.tb00178.x/abstract

Siahaan, T. J., & Lutz, K. (1994). Conformational study of cyclo[Gln-Trp-Phe-Gly-Leu-Met] as NK-2 antagonist by NMR and molecular dynamics. J. Pharm. Biomed. Analysis, 12(1), 65–71. DOI:10.1016/0731-7085(94)80011-1 http://www.sciencedirect.com/science/article/pii/0731708594800111

Siahaan, T. J., Chakrabarti, S. & Vander Velde, D. (1992). Conformational study of cyclo(1,5)-Ac-Pen-Arg-Gly-Asp-Cys-NH2 in water by NMR and molecular dynamics. Biochemical and biophysical research communications, 187(2), 1042–1047. DOI:10.1016/0006-291X(92)91302-7 http://www.sciencedirect.com/science/article/pii/0006291X92913027

Barry, C. E., Bates, R. B., Beavers, W. A., Camou, F. A., Gordon, B. Hsu, H. F., Mills, N. S., Ogle, C. A., Siahaan, T. J., Suvannachut, K. Taylor, S. R., White, J. J., & Yager, K. M. (1991). Delocalized carbanion in synthesis. Synlett., 4, 207–212. DOI:10.1055/s-1991-20682 https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-1991-20682.pdf

Bates, R. B., Siahaan, T. J., & Suvannachut, K. (1990). A new rearrangement of alkoxybenzyl anions. J. Org. Chem., 55, 1328–1334. DOI:10.1021/jo00291a044 http://pubs.acs.org/doi/abs/10.1021/jo00291a044

Lipshutz, B. H., Huff, B. E., McCarthy, K. E., Miller, T. A., Jaweed Mukarram, S. M., Siahaan, T. J., Vaccaro, W. D., Webb, H. & Falick, A. M. (1990). Oxazolophanes as masked cyclopeptide alkaloid equivalents: Cyclic peptide chemistry without peptide couplings. J. Am. Chem. Soc., 112, 7032–7041. DOI:10.1021/ja00175a039 http://pubs.acs.org/doi/abs/10.1021/ja00175a039

Lipshutz, B. H., Ellsworth, E. L., & Siahaan, T. J. (1989). The role of BF3.Et2O in reactions of lower order (Gilman) organocuprates. J. Am. Chem. Soc., 111, 1351–1358. DOI:10.1021/ja00186a031 http://pubs.acs.org/doi/abs/10.1021/ja00186a031

Jolad, S. D., Timmermann, B. N., Hoffmann, J. J., Bates, R. B., Camou, F. A., & Siahaan, T. J. (1988). Grindelane diterpenoids from Isocoma tenuisecta. Phytochem., 27(2), 497–499. DOI:10.1016/0031-9422(88)83129-7 http://www.sciencedirect.com/science/article/pii/0031942288831297

Jolad, S. D., Timmermann, B. N., Hoffmann, J. J., Bates, R. B., Camou, F. A., & Siahaan, T. J. (1988). Kolavane diterpenoids of Vanclevae stylosa. Phytochem., 27(2), 505–515. DOI:10.1016/0031-9422(88)83131-5 http://www.sciencedirect.com/science/article/pii/0031942288831315

Jolad, S. D., Timmernann, B. N., Hoffmann, J. J., Bates, R. B., Camou, F. A., & Siahaan, T. J. (1988). Sesquiterpenoid glycosides and an acetogenin glucoside from Lessingia glandulifera. Phytochemistry, 27(7), 2199–2204. DOI:10.1016/0031-9422(88)80126-2 http://www.sciencedirect.com/science/article/pii/0031942288801262

Lipshutz, B. H., Ellsworth, E. L., Siahaan, T. J., & Shirazi, A. (1988). Unexpected affects of Me3Si-X on reactions of higher order cyanocuprates. Tetrahedron Lett., 29, 6677–6680. DOI:10.1016/S0040-4039(00)82426-0 http://www.sciencedirect.com/science/article/pii/S0040403900824260

Tsonis, P. A., Carperos, V. & Siahaan, T. J. (1988). Modeling of the homoeo domain suggests similar structure to repressors. Biochemical and biophysical research communications, 157(1), 100–105. DOI:10.1016/S0006-291X(88)80017-2 http://www.sciencedirect.com/science/article/pii/S0006291X88800172

Lipshutz, B. H., Ellsworth, E. L., & Siahaan, T. J. (1988). Effects of BF3.Et2O on higher order organocuprate reactions: Substrate activation or cuprate modification? J. Am. Chem. Soc., 110, 4834–4835. DOI:10.1021/ja00222a055 http://pubs.acs.org/doi/abs/10.1021/ja00222a055

Hoffmann, J. J., Jolad, S. D., Timmermann, B. N., Bates, R. B., Camou, F. A., & Siahaan, T. J. (1987). A new diterpenoid from Ericameria laricifolia. Phytochem., 26, 2861–2863. DOI:10.1016/S0031-9422(00)83610-9 http://www.sciencedirect.com/science/article/pii/S0031942200836109

Sardesai, L. G., Paknikar, S. K., Bates, R. B., Siahaan, T. J., Kane, V. V., & Mishra, P. K. (1987). A new heterocyclic system from salol and phenylacetic acid. Heterocycles, 26, 2941–2944. DOI:10.3987/R-1987-11-2941 https://www.heterocycles.jp/newlibrary/payments/form/12087/PDF

Timmermann, B. N., Hoffmann, J. J., Jolad, S. D., Bates, R. B., & Siahaan, T. J. (1987). Five grindelane diterpenoids from Grindelia acutifolia. Phytochem., 26, 467–470. DOI:10.1016/S0031-9422(00)81434-X http://www.sciencedirect.com/science/article/pii/S003194220081434X

Jolad, S. D., Timmermann, B. N., Hoffmann, J. J., Bates, R. B., & Siahaan, T. J. (1987). Havardic acids A-F, and havardiol, labdane diterpenoids from Grindelia havardii. Phytochem., 26, 483-489. DOI:10.1016/S0031-9422(00)81438-7 http://www.sciencedirect.com/science/article/pii/S0031942200814387

Bates, R. B., Siahaan, T. J., Suvannachut, K. Vasey, S. K., & Yager, K. M. (1987). Preparation and reactions of trianions from the dimethylphenols. J. Org. Chem., 52, 4605–4608. DOI:10.1021/jo00229a032 http://pubs.acs.org/doi/abs/10.1021/jo00229a032

Bates, R. B., Roberts, S. A., Siahaan, T. J., Gnanasambandan, T. & Yalkowsky, S. H. (1986). 9,10-Anthracenedicarbaldehyde bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] acetic acid hydrochloric acid trihydrate salt (Bisantrene). Acta Cryst., C42, 186–188. DOI:10.1107/S010827018609683X http://onlinelibrary.wiley.com/doi/10.1107/S010827018609683X/abstract

Jolad, J. D., Bates, R. B., Cole, J. R., Hoffmann, J. J., Siahaan, T. J., & Timmermann, B. N. (1986). Cardenolides and a lignan from Asclepias subulata. Phytochem., 25, 2581–2590. DOI:10.1016/S0031-9422(00)84515-X http://www.sciencedirect.com/science/article/pii/S003194220084515X

Timmermann, B. N., Hoffmann, J. J., Jolad, S. D., Bates, R. B., & Siahaan, T. J. (1986). Labdane diterpenoids from Grindelia discoidea (Asteraceae). Phytochem., 25, 1389–1392. DOI:10.1016/S0031-9422(00)81295-9 http://www.sciencedirect.com/science/article/pii/S0031942200812959

Awards & Honors —

Fellow of the American Association of Pharmaceutical Scientists, American Association of Pharmaceutical Scientists (2002 - Present)
PhRMA Foundation Award in Excellence in Pharmaceutics, PhRMA Foundation, USA (2014)
Mentor of the Year, Office for Diversity in Science Training, The University of Kansas (2013)
J Clarence Karcher Lecturer, University of Oklahoma (2005)
Research Scholar Award, Pfizer (2002 - 2005)
Madison and Lila Self Faculty Scholar, University of Kansas (2001 - 2004)
Eurand Award, Honorable Mention, Controlled Release Society (2002)
Clark W. Smith Fellowship, The University of Arizona (1985)
Department of Chemistry Fellowship, The University of Arizona (1984)