• Associate Professor
School of Pharmacy - Pharmaceutical Chemistry
785-864-2626
Office
Simons Biosciences Research Laboratories, Room 236-B
University of Kansas
2095 Constant Avenue
Lawrence, KS 66047

Education

  • Postdoctoral, Department of Biochemistry, Stanford University School of Medicine, Stanford, CA (1998 - 2001)
  • Postdoctoral, Victorian College of Pharmacy (now Monash University), Melbourne, Austrailia
  • Ph.D. (w/honors), Pharmaceutical Chemistry, University of Kansas, Lawrence, KS (1998)
  • B.S., Pharmacy, Duquesne University, Pittsburgh, PA (1993)

Experience

Professional Experience

  • Associate Professor, University of Kansas, Department of Pharmaceutical Chemistry (2004 - present)
  • University of North Carolina at Chapel Hill, Division of Drug Delivery (2001)

Research Overview

The Krise laboratory seeks to understand how drugs distribute and localize within human cells and how this influences their therapeutic activity and pharmacokinetic distribution properties. Much of our recent studies have focused on the intracellular distribution of amine-containing drugs and their propensity to become highly concentrated in acidic intracellular compartments such as lysosomes according to an ion trapping-type mechanism.

Research Interests

  • Drug delivery
  • Pharmacokinetics
  • Prodrugs
  • Intracellular

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Research

Our research projects ranging from traditional pharmaceutics to biotechnology. 

Learn more here.

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