Professor Brandon DeKosky earned a B.S. in Chemical Engineering from the University of Kansas in 2010 and a Ph.D. in Biochemical Engineering from the University of Texas at Austin in 2015. He completed a Post Doc in Immunology & Vaccinology at the Vaccine Research Center, National Institute of Allergy and Infectious Diseases in Bethesda, MD in 2017.
Next-generation DNA sequencing technologies have revolutionized the way that immunologists and biotechnologists study adaptive immune responses to vaccination and disease. The DeKosky laboratory works to invent and apply advanced NextGen molecular biology techniques to accelerate development of new human vaccines and therapeutics. We have a special focus on understanding highly effective human antibody responses to persistent viral infections (including HIV, EBV, CMV), and in characterizing the antibody response to experimental vaccines.
For more information please see our lab webpage, http://www.dekoskylab.org .
Google Scholar link: https://scholar.google.com/citations?user=z6TwVlwAAAAJ&hl=en
DeKosky BJ, Kojima T, Rodin A, Charab W, Ippolito GC, Ellington AD, Georgiou G. In-depth determination and analysis of the human paired heavy and light chain antibody repertoire. Nature Medicine, 21, 86–91. 2014
McDaniel JR*, DeKosky BJ*, Tanno H, Ellington AD, Georgiou G, "Ultra-high throughput sequencing of the immune receptor repertoire from millions of lymphocytes," Nature Protocols. 11: 429-442. 2016
DeKosky, B. J., Lungu, O. I., Park, D., Johnson, E. L., Charab, W., Chrysostomou, C., Kuroda, D., Ellington, A. D., Ippolito, G. C., Gray, J. J. & Georgiou, G. Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires. Proceedings of the National Academy of Sciences. 113: E2636–E2645. 2016
Tian M*, Cheng C*, Chen X*, Duan H*, Cheng HL*, Dao M, Sheng Z, Kimble M, Wang L, Lin S, Schmidt SD, Du Z, Joyce MG, Chen Y, DeKosky BJ, Chen Y, Normandin E, Cantor E, Chen RE, Doria-Rose NA, Zhang Y, Shi W, Kong WP, Choe M, Henry AR, Laboune F, Georgiev IS, Huang PY, Jain S, McGuire AT, Georgeson E, Menis S, Douek DC, Schief WR, Stamatatos L, Kwong PD, Shapiro L, Haynes BF, Mascola JR & Alt FW. Induction of HIV neutralizing antibody lineages in mice with diverse precursor repertoires. Cell 166, 1471–1484.e18. 2016